(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170


ANTI BACTERIAL ACTIVITY OF NEEM (Azadirachta indica) LEAF EXTRACT ON Klebsiella pneumoniae AND Staphlococcus aureus IN ZARIA, KADUNA STATE
Pages: 133-137
H. Musa, K. A. Doguwa, G. Y. Sambo and G. S. Mete

keywords: Antibacterial, aqueous extracts, infections, maximum inhibitory


Azadirachta indica commonly known as neem is a medicinal plant belonging to the family Meliaceae. The research was carried out to determine the antimicrobial effects of aqueous extracts of the leaves of Azadirachta indica using minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of extracts as indices. Clinical isolates of Klebsiella pneumoniae and Staphylococcus aureus were used as test organisms. For the aqueous extract of the leaves, a minimum concentration of 125 mg/ml was found to inhibit the growth of K. pneumoniae and S. aureus in nutrient broth. MBC for K. pneumoniae and S. aureus are 250 and 250 mg/ml, respectively. The aqueous extracts of A. indica showed relatively strong antimicrobial activity, inhibiting the growth of bacterial isolates used which therefore indicates that the plant has antibacterial properties. It may be attributed to the high active compounds from the sample unlike the low volatility of some extracts such as ethanol. It is recommended that management studies should be carried out on the plant to explore its usage as a possibility of treatment for pathogenic bacterial infections.


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