keywords: Anchomanes difformis, Araceae, α-amylase, α-Glucosidase, Antioxidant
The primary stage of diabetes mellitus type 2 is linked with postprandial hyperglycemia. This is believed to increase the production of free radicals and reactive oxygen species, leading to oxidative tissue damage. In an effort to identify herbal drugs which may be useful in the prevention or mitigation of diabetes, the antioxidant activities, in vitro α-amylase and glucosidase inhibition of methanol extract from the tuber of Anchomanes difformis was studied. The extract showed total phenol content (TPC) 442.7 ±2.28 GAE mg/100g and ferric-reducing antioxidant power (FRAP) 176.6 ±3.31 AAEmg/100g. At the maximum concentration 100 μg/ml, the metal ion inhibition, DPPH radical scavenging activity and nitric oxide scavenging activity are 43.3, 34.9 and 58.6 μg/ml, respectively. The plant did not show prominent α- amylase and glucosidase inhibitory activity (IC50˃100 μg/ml). This study shows that A. difformis contains phenolic compounds that can be useful in the prevention or mitigation of cellular damages linked to diabetic conditions.
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